A Brief History of Everyone Who Ever Lived: the human story retold through our genes by
In our unique genomes, every one of us carries the story of our species--births, deaths, disease, war, famine, migration, and a lot of sex. But those stories have always been locked away--until now. Who are our ancestors? Where did they come from? Geneticists have suddenly become historians, and the hard evidence in our DNA has blown the lid off what we thought we knew. Acclaimed science writer Adam Rutherford explains exactly how genomics is completely rewriting the human story--from 100,000 years ago to the present. A Brief History of Everyone Who Ever Lived will upend your thinking on Neanderthals, evolution, royalty, race, and even redheads. (For example, we now know that at least four human species once roamed the earth.) Plus, here is the remarkable, controversial story of how our genes made their way to the Americas--one that's still being written, as ever more of us have our DNA sequenced. Rutherford closes with "A Short Introduction to the Future of Humankind," filled with provocative questions that we're on the cusp of answering: Are we still in the grasp of natural selection? Are we evolving for better or worse? And . . . where do we go from here?
The code breaker : Jennifer Doudna, gene editing, and the future of the human race by
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how the pioneering scientist Jennifer Doudna, along with her colleagues and rivals, launched a revolution that will allow us to cure diseases, fend off viruses, and enhance our children"--
Driven by a passion to understand how nature works and to turn discoveries into inventions, Doudna and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. Isaacson explores the development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution.
A Crack in Creation: gene editing and the unthinkable power to control evolution by
Two Berkeley scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.
CRISPR People: the science and ethics of editing humans by
In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention
The Gene: an intimate history by
The story of the gene begins in earnest in an obscure Augustinian abbey in Moravia in 1856 where Gregor Mendel, a monk working with pea plants, stumbles on the idea of a "unit of heredity." It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms postwar biology. It invades discourses concerning race and identity and provides startling answers to some of the most potent questions coursing through our political and cultural realms. It reorganizes our understanding of sexuality, gender identity, sexual orientation, temperament, choice, and free will, thus raising the most urgent questions affecting our personal realms. Above all, the story of the gene is driven by human ingenuity and obsessive minds -- from Mendel and Darwin to Francis Crick, James Watson, and Rosalind Franklin to the thousands of scientists working today to understand the code of codes. Woven through the book is the story of author Mukherjee's own family and its recurring pattern of schizophrenia, a haunting reminder that the science of genetics is not confined to the laboratory but is vitally relevant to everyday lives. The moral complexity of genetics reverberates even more urgently today as we learn to "read" and "write" the human genome -- unleashing the potential to change the fates and identities of our children and our children's children.
Our genes are the master-code of instructions that makes and defines humans; it governs our form, function, and fate, and that determines the future of our children. The story of the gene begins in earnest in an obscure Augustinian abbey in Moravia in 1856 as Mendel's idea of a "unit of heredity;" intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. Mukherjee tells the story of her own family and its recurring pattern of schizophrenia, a haunting reminder that the science of genetics is not confined to the laboratory but is vitally relevant to everyday lives.
Genetics for Dummies by
A practical guide that gets you up to speed on all the fundamentals and the most recent discoveries in genetics, in easy-to-understand terms. You'll see how people are applying genetic science to fight disease, develop new products, solve crimes-- and even clone cats!
Human Genetics: The Basics by
Human genetics has blossomed from an obscure branch of biological science and occasional explanation for exceedingly rare disorders to a field all of its own that affects everyone. Human Genetics: The Basics introduces the key questions and issues in this emerging field, including:
The common ancestry of all humanity The role of genes in sickness and health Debates over the use of genetic technology
Written in an engaging, narrative manner, this concise introduction is an ideal starting point for anyone who wants to know more about genes, DNA, and the genetic ties that bind us all.
She Has Her Mother's Laugh: the powers, perversions, and potential of heredity by
Presents a history of the human understanding of heredity and how it has shaped society, chronicling the transitions brought about by genetic research and making predictions about how evolving understandings are likely to impact the future.
Some Assembly Required : decoding four billion years of life, from ancient fossils to DNA by
"The author of the best-selling Your Inner Fish, now gives us a lively and accessible account of the great transformations in the history of life, that enable us to further understand whether our presence on this planet is an accident or inevitable. The great transformations in the history of life brought about whole scale shifts in how animals live and how their bodies are organized: the evolution of fish to land-living creature, the origin of birds, the beginnings of bodies in single-celled creatures. Shubin describes how over the last half-century, scientists have been able to explore how genetic recipes build bodies during embryological development--how these inventions and adaptations occur in a nonprogressive manner in different contexts, at different speeds. Paleontology has been transformed over the last 50 years by tools and techniques of molecular biology--and it is that revolution in our understanding of the evolution of life that Shubin traces here. Each of us is a mosaic of precursors that came about at different times and places, with deep rooted connections across species that Darwin, for all he understood, could never even have imagined"
The Future of Genetics : Beyond the Human Genome Project by 
Hacking Darwin : Genetic Engineering and the Future of Humanity by
"A gifted and thoughtful writer, Metzl brings us to the frontiers of biology and technology, and reveals a world full of promise and peril." — Siddhartha Mukherjee MD, New York Times bestselling author of The Emperor of All Maladies and The Gene. Passionate, provocative, and highly illuminating, Hacking Darwin is the must read book about the future of our species for fans of Homo Deus and The Gene. After 3.8 billion years humankind is about to start evolving by new rules... From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives — sex, war, love, and death. At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race. Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?
How Genes Matter : Genetic Medicine As Subjectivisation Practices by
Understanding the significance of genetic factors for our lives requires an analysis that goes beyond biological aspects. It is especially necessary to take into account how human beings relate to others and to themselves. Who we are is a result of social action and the ways in which human beings constitute themselves as subjects. Seen from this perspective, genetic medicine is a social practice that shapes how we think about us, how we conduct our behaviour and how we care for our children. This book scrutinises practices by which individuals become knowledgeable about their genes and constitute them as responsible decision makers.
An Introduction to Molecular Anthropology by
Molecular anthropology uses molecular genetic methods to address questions and issues of anthropological interest. More specifically, molecular anthropology is concerned with genetic evidence concerning human origins, migrations, and population relationships, including related topics such as the role of recent natural selection in human population differentiation, or the impact of particular social systems on patterns of human genetic variation. Organized into three major sections, An Introduction to Molecular Anthropology first covers the basics of genetics - what genes are, what they do, and how they do it - as well as how genes behave in populations and how evolution influences them. The following section provides an overview of the different kinds of genetic variation in humans, and how this variation is analyzed and used to make evolutionary inferences. The third section concludes with a presentation of the current state of genetic evidence for human origins, the spread of humans around the world, the role of selection and adaptation in human evolution, and the impact of culture on human genetic variation. A final, concluding chapter discusses various aspects of molecular anthropology in the genomics era, including personal ancestry testing and personal genomics. An Introduction to Molecular Anthropology is an invaluable resource for students studying human evolution, biological anthropology, or molecular anthropology, as well as a reference for anthropologists and anyone else interested in the genetic history of humans.
Redesigning Life : How Genome Editing Will Transform the World by
Since the birth of civilisation, human beings have manipulated other life-forms.We have selectively bred plants and animals for thousands of years to maximise agricultural production and cater to our taste in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice weremodified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering.In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. 'Mutation chain reaction' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almostcompletely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch.These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers,pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring -- and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms intocomplex ecosystems? In this extensively revised paperback edition, John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.
